T65.84UpcomingCategory · further specificity required

Toxic effect of xylazine

Code-level instructions

Use additional code

code(s) for all associated manifestations, such as:
cellulitis and acute lymphangitis (L03.-)
cutaneous abscess, furuncle and carbuncle (L02.-)
non-pressure chronic ulcer of lower limb, not elsewhere classified (L97.-)
non-pressure chronic ulcer of skin, not elsewhere classified (L98.4-)

Chapters 19 · Inherited instructions

Use additional code

code to identify any retained foreign body, if applicable (Z18.-)

T51-T65 · Inherited instructions

Use additional code

code(s):
for all associated manifestations of toxic effect, such as: respiratory conditions due to external agents (J60-J70)
personal history of foreign body fully removed (Z87.821)
to identify any retained foreign body, if applicable (Z18.-)

Excludes 1

contact with and (suspected) exposure to toxic substances (Z77.-)

T65 · Inherited instructions

A — initial encounter

D — subsequent encounter

S — sequela

Excludes 2 · 2

Chapters 19 · Injury, poisoning and certain other consequences of external causes (S00-T88)

Excludes 2

birth trauma (P10-P15)
obstetric trauma (O70-O71)

More specific codes

T65.841Toxic effect of xylazine, accidental (unintentional)T65.842Toxic effect of xylazine, intentional self-harm T65.843Toxic effect of xylazine, assault T65.844Toxic effect of xylazine, undetermined

Claims & coverage

When ICD-10-CM is required

For US diagnosis claims covered by HIPAA, ICD-10-CM is required from October 1, 2015.

Use the service date for outpatient/professional claims and the discharge date for hospital inpatient claims. Earlier encounters use ICD-9-CM; each individual code must also be valid for the applicable date.

Official coding guidelines → · CMS ↗

First observed · 2025-10-01

Code history

Latest recorded change · FY2026

ChangedUnchanged

FY2026

Effective from 2025-10-01

Added

Toxic effect of xylazine

Category — select a more specific code

CDC/NCHS · FY2026

All editions (3)

All editions	Effective from	Code history
FY2026	2025-10-01	Added
FY2026 · April	2026-04-01	No tabular change
FY2027	2026-10-01	No tabular change

Code-level instructions

Use additional code

code(s) for all associated manifestations, such as:
cellulitis and acute lymphangitis (L03.-)
cutaneous abscess, furuncle and carbuncle (L02.-)
non-pressure chronic ulcer of lower limb, not elsewhere classified (L97.-)
non-pressure chronic ulcer of skin, not elsewhere classified (L98.4-)

Inherited instructions

Chapters 19 · Injury, poisoning and certain other consequences of external causes (S00-T88)

Excludes 2

birth trauma (P10-P15)
obstetric trauma (O70-O71)

Use additional code

code to identify any retained foreign body, if applicable (Z18.-)

Note

Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.

T51-T65 · Toxic effects of substances chiefly nonmedicinal as to source (T51-T65)

Excludes 1

contact with and (suspected) exposure to toxic substances (Z77.-)

Use additional code

code(s):
for all associated manifestations of toxic effect, such as: respiratory conditions due to external agents (J60-J70)
personal history of foreign body fully removed (Z87.821)
to identify any retained foreign body, if applicable (Z18.-)

Note

When no intent is indicated code to accidental. Undetermined intent is only for use when there is specific documentation in the record that the intent of the toxic effect cannot be determined.

T65 · Toxic effect of other and unspecified substances

Seventh character

The appropriate 7th character is to be added to each code from category T65

A — initial encounter

D — subsequent encounter

S — sequela

More specific codes

T65.841Toxic effect of xylazine, accidental (unintentional)Category · further specificity required T65.842Toxic effect of xylazine, intentional self-harmCategory · further specificity required T65.843Toxic effect of xylazine, assaultCategory · further specificity required T65.844Toxic effect of xylazine, undeterminedCategory · further specificity required

Related codes

Other entries in the same category; these are not automatic substitutes.

Code	Description	Category · further specificity required
T65.81	Toxic effect of latex	Category · further specificity required
T65.82	Toxic effect of harmful algae and algae toxins	Category · further specificity required
T65.83	Toxic effect of fiberglass	Category · further specificity required
T65.85	Toxic effect of medetomidine	Category · further specificity required
T65.89	Toxic effect of other specified substances	Category · further specificity required

Official titles and instructions are preserved in their source language. Official sources ↗

T65.84UpcomingCategory · further specificity required

Toxic effect of xylazine

Code-level instructions

Use additional code

code(s) for all associated manifestations, such as:
cellulitis and acute lymphangitis (L03.-)
cutaneous abscess, furuncle and carbuncle (L02.-)
non-pressure chronic ulcer of lower limb, not elsewhere classified (L97.-)
non-pressure chronic ulcer of skin, not elsewhere classified (L98.4-)

Chapters 19 · Inherited instructions

Use additional code

code to identify any retained foreign body, if applicable (Z18.-)

T51-T65 · Inherited instructions

Use additional code

code(s):
for all associated manifestations of toxic effect, such as: respiratory conditions due to external agents (J60-J70)
personal history of foreign body fully removed (Z87.821)
to identify any retained foreign body, if applicable (Z18.-)

Excludes 1

contact with and (suspected) exposure to toxic substances (Z77.-)

T65 · Inherited instructions

A — initial encounter

D — subsequent encounter

S — sequela

Excludes 2 · 2

Chapters 19 · Injury, poisoning and certain other consequences of external causes (S00-T88)

Excludes 2

birth trauma (P10-P15)
obstetric trauma (O70-O71)

More specific codes

Claims & coverage

When ICD-10-CM is required

For US diagnosis claims covered by HIPAA, ICD-10-CM is required from October 1, 2015.

Official coding guidelines → · CMS ↗

First observed · 2025-10-01

Code history

Latest recorded change · FY2026

ChangedUnchanged

FY2026

Effective from 2025-10-01

Added

Toxic effect of xylazine

Category — select a more specific code

CDC/NCHS · FY2026

All editions (3)

All editions	Effective from	Code history
FY2026	2025-10-01	Added
FY2026 · April	2026-04-01	No tabular change
FY2027	2026-10-01	No tabular change

Code-level instructions

Use additional code

code(s) for all associated manifestations, such as:
cellulitis and acute lymphangitis (L03.-)
cutaneous abscess, furuncle and carbuncle (L02.-)
non-pressure chronic ulcer of lower limb, not elsewhere classified (L97.-)
non-pressure chronic ulcer of skin, not elsewhere classified (L98.4-)

Inherited instructions

Chapters 19 · Injury, poisoning and certain other consequences of external causes (S00-T88)

Excludes 2

birth trauma (P10-P15)
obstetric trauma (O70-O71)

Use additional code

code to identify any retained foreign body, if applicable (Z18.-)

Note

Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.

T51-T65 · Toxic effects of substances chiefly nonmedicinal as to source (T51-T65)

Excludes 1

contact with and (suspected) exposure to toxic substances (Z77.-)

Use additional code

code(s):
for all associated manifestations of toxic effect, such as: respiratory conditions due to external agents (J60-J70)
personal history of foreign body fully removed (Z87.821)
to identify any retained foreign body, if applicable (Z18.-)

Note

When no intent is indicated code to accidental. Undetermined intent is only for use when there is specific documentation in the record that the intent of the toxic effect cannot be determined.

T65 · Toxic effect of other and unspecified substances

Seventh character

The appropriate 7th character is to be added to each code from category T65

A — initial encounter

D — subsequent encounter

S — sequela

More specific codes

Related codes

Other entries in the same category; these are not automatic substitutes.

Code	Description	Category · further specificity required
T65.81	Toxic effect of latex	Category · further specificity required
T65.82	Toxic effect of harmful algae and algae toxins	Category · further specificity required
T65.83	Toxic effect of fiberglass	Category · further specificity required
T65.85	Toxic effect of medetomidine	Category · further specificity required
T65.89	Toxic effect of other specified substances	Category · further specificity required

Official titles and instructions are preserved in their source language. Official sources ↗