T65UpcomingCategory · further specificity required

Toxic effect of other and unspecified substances

Code-level instructions

A — initial encounter

D — subsequent encounter

S — sequela

Chapters 19 · Inherited instructions

Use additional code

code to identify any retained foreign body, if applicable (Z18.-)

T51-T65 · Inherited instructions

Use additional code

code(s):
for all associated manifestations of toxic effect, such as: respiratory conditions due to external agents (J60-J70)
personal history of foreign body fully removed (Z87.821)
to identify any retained foreign body, if applicable (Z18.-)

Excludes 1

contact with and (suspected) exposure to toxic substances (Z77.-)

Excludes 2 · 2

Chapters 19 · Injury, poisoning and certain other consequences of external causes (S00-T88)

Excludes 2

birth trauma (P10-P15)
obstetric trauma (O70-O71)

More specific codes

T65.0Toxic effect of cyanides T65.1Toxic effect of strychnine and its salts T65.2Toxic effect of tobacco and nicotine T65.3Toxic effect of nitroderivatives and aminoderivatives of benzene and its homologues T65.4Toxic effect of carbon disulfide T65.5Toxic effect of nitroglycerin and other nitric acids and esters T65.6Toxic effect of paints and dyes, not elsewhere classified T65.8Toxic effect of other specified substances T65.9Toxic effect of unspecified substance

Claims & coverage

When ICD-10-CM is required

For US diagnosis claims covered by HIPAA, ICD-10-CM is required from October 1, 2015.

Use the service date for outpatient/professional claims and the discharge date for hospital inpatient claims. Earlier encounters use ICD-9-CM; each individual code must also be valid for the applicable date.

Official coding guidelines → · CMS ↗

First observed · 2015-10-01

Code history

Latest recorded change · FY2025 · 04-01

ChangedUnchanged

FY2025 · 04-01

Effective from 2025-04-01

Inherited rules changed

Toxic effect of other and unspecified substances

Category — select a more specific code

CDC/NCHS · FY2025 · 04-01

All editions (19)

All editions	Effective from	Code history
FY2016	2015-10-01	First observed
FY2017	2016-10-01	No tabular change
FY2018	2017-10-01	No tabular change
FY2019	2018-10-01	No tabular change
FY2020	2019-10-01	No tabular change
FY2020 · April	2020-04-01	No tabular change
FY2021	2020-10-01	No tabular change
FY2021 · 01-01	2021-01-01	No tabular change
FY2022	2021-10-01	No tabular change
FY2022 · 04-01	2022-04-01	No tabular change
FY2023	2022-10-01	No tabular change
FY2023 · 04-01	2023-04-01	No tabular change
FY2024	2023-10-01	No tabular change
FY2024 · 04-01	2024-04-01	No tabular change
FY2025	2024-10-01	No tabular change
FY2025 · 04-01	2025-04-01	Inherited rules changed
FY2026	2025-10-01	No tabular change
FY2026 · April	2026-04-01	No tabular change
FY2027	2026-10-01	No tabular change

Code-level instructions

Seventh character

The appropriate 7th character is to be added to each code from category T65

A — initial encounter

D — subsequent encounter

S — sequela

Inherited instructions

Chapters 19 · Injury, poisoning and certain other consequences of external causes (S00-T88)

Excludes 2

birth trauma (P10-P15)
obstetric trauma (O70-O71)

Use additional code

code to identify any retained foreign body, if applicable (Z18.-)

Note

Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.

T51-T65 · Toxic effects of substances chiefly nonmedicinal as to source (T51-T65)

Excludes 1

contact with and (suspected) exposure to toxic substances (Z77.-)

Use additional code

code(s):
for all associated manifestations of toxic effect, such as: respiratory conditions due to external agents (J60-J70)
personal history of foreign body fully removed (Z87.821)
to identify any retained foreign body, if applicable (Z18.-)

Note

When no intent is indicated code to accidental. Undetermined intent is only for use when there is specific documentation in the record that the intent of the toxic effect cannot be determined.

More specific codes

Related codes

Official titles and instructions are preserved in their source language. Official sources ↗

References from other codes (72)

D61.2 · Aplastic anemia due to other external agents

Code first · , if applicable, toxic effects of substances chiefly nonmedicinal as to source (T51-T65)

D64.2 · Secondary sideroblastic anemia due to drugs and toxins

Code first · poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)

E03.2 · Hypothyroidism due to medicaments and other exogenous substances

Code first · poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)

E09 · Drug or chemical induced diabetes mellitus

Code first · poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)

F02 · Dementia in other diseases classified elsewhere

Code first · intoxications (T36-T65)

G21.2 · Secondary parkinsonism due to other external agents

Code first · (T51-T65) to identify external agent

G62.2 · Polyneuropathy due to other toxic agents

Code first · (T51-T65) to identify toxic agent

G70.1 · Toxic myoneural disorders

Code first · (T51-T65) to identify toxic agent

G72.2 · Myopathy due to other toxic agents

Code first · (T51-T65) to identify toxic agent

G92.8 · Other toxic encephalopathy

Code first · poisoning due to drug or toxin, if applicable, (T36-T65 with fifth or sixth character 1-4)

G92.9 · Unspecified toxic encephalopathy

Code first · poisoning due to drug or toxin, if applicable, (T36-T65 with fifth or sixth character 1-4)

H10.21 · Acute toxic conjunctivitis

Code first · (T51-T65) to identify chemical and intent

H35.38 · Toxic maculopathy

Code first · poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)

H46.3 · Toxic optic neuropathy

Code first · (T51-T65) to identify cause

H91.0 · Ototoxic hearing loss

Code first · poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)

I42.7 · Cardiomyopathy due to drug and external agent

Code first · poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)

J68 · Respiratory conditions due to inhalation of chemicals, gases, fumes and vapors

Code first · (T51-T65) to identify cause

J69.1 · Pneumonitis due to inhalation of oils and essences

Code first · (T51-T65) to identify substance

J69.8 · Pneumonitis due to inhalation of other solids and liquids

Code first · (T51-T65) to identify substance

J70.8 · Respiratory conditions due to other specified external agents

Code first · (T51-T65) to identify the external agent

J70.9 · Respiratory conditions due to unspecified external agent

Code first · (T51-T65) to identify the external agent

J84.89 · Other specified interstitial pulmonary diseases

Code first · poisoning due to drug or toxin (T51-T65 with fifth or sixth character to indicate intent), for toxic pneumonopathy

K22.1 · Ulcer of esophagus

Code first · poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)

K52.1 · Toxic gastroenteritis and colitis

Code first · (T51-T65) to identify toxic agent

K59.3 · Megacolon, not elsewhere classified

Code first · , if applicable (T51-T65) to identify toxic agent

K71 · Toxic liver disease

Code first · poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)

L53.0 · Toxic erythema

Code first · poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)

M34.2 · Systemic sclerosis induced by drug and chemical

Code first · poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)

N14 · Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions

Code first · poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)

P58.4 · Neonatal jaundice due to drugs or toxins transmitted from mother or given to newborn

Code first · poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)

T20.4 · Corrosion of unspecified degree of head, face, and neck

Code first · (T51-T65) to identify chemical and intent

T20.5 · Corrosion of first degree of head, face, and neck

Code first · (T51-T65) to identify chemical and intent

T20.6 · Corrosion of second degree of head, face, and neck

Code first · (T51-T65) to identify chemical and intent

T20.7 · Corrosion of third degree of head, face, and neck

Code first · (T51-T65) to identify chemical and intent

T21.4 · Corrosion of unspecified degree of trunk

Code first · (T51-T65) to identify chemical and intent

T21.5 · Corrosion of first degree of trunk

Code first · (T51-T65) to identify chemical and intent

T21.6 · Corrosion of second degree of trunk

Code first · (T51-T65) to identify chemical and intent

T21.7 · Corrosion of third degree of trunk

Code first · (T51-T65) to identify chemical and intent

T22.4 · Corrosion of unspecified degree of shoulder and upper limb, except wrist and hand

Code first · (T51-T65) to identify chemical and intent

T22.5 · Corrosion of first degree of shoulder and upper limb, except wrist and hand

Code first · (T51-T65) to identify chemical and intent

T22.6 · Corrosion of second degree of shoulder and upper limb, except wrist and hand

Code first · (T51-T65) to identify chemical and intent

T22.7 · Corrosion of third degree of shoulder and upper limb, except wrist and hand

Code first · (T51-T65) to identify chemical and intent

T23.4 · Corrosion of unspecified degree of wrist and hand

Code first · (T51-T65) to identify chemical and intent

T23.5 · Corrosion of first degree of wrist and hand

Code first · (T51-T65) to identify chemical and intent

T23.6 · Corrosion of second degree of wrist and hand

Code first · (T51-T65) to identify chemical and intent

T23.7 · Corrosion of third degree of wrist and hand

Code first · (T51-T65) to identify chemical and intent

T24.4 · Corrosion of unspecified degree of lower limb, except ankle and foot

Code first · (T51-T65) to identify chemical and intent

T24.5 · Corrosion of first degree of lower limb, except ankle and foot

Code first · (T51-T65) to identify chemical and intent

T24.6 · Corrosion of second degree of lower limb, except ankle and foot

Code first · (T51-T65) to identify chemical and intent

T24.7 · Corrosion of third degree of lower limb, except ankle and foot

Code first · (T51-T65) to identify chemical and intent

T25.4 · Corrosion of unspecified degree of ankle and foot

Code first · (T51-T65) to identify chemical and intent

T25.5 · Corrosion of first degree of ankle and foot

Code first · (T51-T65) to identify chemical and intent

T25.6 · Corrosion of second degree of ankle and foot

Code first · (T51-T65) to identify chemical and intent

T25.7 · Corrosion of third degree of ankle and foot

Code first · (T51-T65) to identify chemical and intent

T26.5 · Corrosion of eyelid and periocular area

Code first · (T51-T65) to identify chemical and intent

T26.6 · Corrosion of cornea and conjunctival sac

Code first · (T51-T65) to identify chemical and intent

T26.7 · Corrosion with resulting rupture and destruction of eyeball

Code first · (T51-T65) to identify chemical and intent

T26.8 · Corrosions of other specified parts of eye and adnexa

Code first · (T51-T65) to identify chemical and intent

T26.9 · Corrosion of eye and adnexa, part unspecified

Code first · (T51-T65) to identify chemical and intent

T27.4 · Corrosion of larynx and trachea

Code first · (T51-T65) to identify chemical and intent

T27.5 · Corrosion involving larynx and trachea with lung

Code first · (T51-T65) to identify chemical and intent

T27.6 · Corrosion of other parts of respiratory tract

Code first · (T51-T65) to identify chemical and intent

T27.7 · Corrosion of respiratory tract, part unspecified

Code first · (T51-T65) to identify chemical and intent

T28.5 · Corrosion of mouth and pharynx

Code first · (T51-T65) to identify chemical and intent

T28.6 · Corrosion of esophagus

Code first · (T51-T65) to identify chemical and intent

T28.7 · Corrosion of other parts of alimentary tract

Code first · (T51-T65) to identify chemical and intent

T28.8 · Corrosion of internal genitourinary organs

Code first · (T51-T65) to identify chemical and intent

T28.9 · Corrosions of other and unspecified internal organs

Code first · (T51-T65) to identify chemical and intent

T81 · Complications of procedures, not elsewhere classified

Excludes 2 · poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4)

T88 · Other complications of surgical and medical care, not elsewhere classified

Excludes 2 · poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4)

Z77 · Other contact with and (suspected) exposures hazardous to health

Excludes 2 · toxic effects of substances chiefly nonmedicinal as to source (T51-T65)

sections/T80-T88 · Complications of surgical and medical care, not elsewhere classified (T80-T88)

Excludes 2 · poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)