K52.21UpcomingBillable / specific

Food protein-induced enterocolitis syndrome

Code-level instructions

Use additional code

code for hypovolemic shock, if present (R57.1)

K52.2 · Inherited instructions

Use additional code

code to identify type of food allergy (Z91.01-, Z91.02-)

K50-K52 · Inherited instructions

Excludes 1

irritable bowel syndrome (K58.-)
megacolon (K59.3-)

Excludes 2 · 12

K52.2 · Allergic and dietetic gastroenteritis and colitis

Excludes 2

allergic eosinophilic colitis (K52.82)
allergic eosinophilic esophagitis (K20.0)
allergic eosinophilic gastritis (K52.81)
allergic eosinophilic gastroenteritis (K52.81)

Chapters 11 · Diseases of the digestive system (K00-K95)

Excludes 2

certain conditions originating in the perinatal period (P04-P96)
certain infectious and parasitic diseases (A00-B99)
complications of pregnancy, childbirth and the puerperium (O00-O9A)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E88)
injury, poisoning and certain other consequences of external causes (S00-T88)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Claims & coverage

Coverage depends on the payer, service and applicable policy. A billable code does not guarantee payment.

When ICD-10-CM is required

For US diagnosis claims covered by HIPAA, ICD-10-CM is required from October 1, 2015.

Use the service date for outpatient/professional claims and the discharge date for hospital inpatient claims. Earlier encounters use ICD-9-CM; each individual code must also be valid for the applicable date.

Official coding guidelines → · CMS ↗

Check Medicare coverage ↗

First observed · 2016-10-01

Code history

Latest recorded change · FY2022

ChangedUnchanged

FY2022

Effective from 2021-10-01

Inherited rules changed

Food protein-induced enterocolitis syndrome

Billable diagnosis code

CDC/NCHS · FY2022

All editions (18)

All editions	Effective from	Code history
FY2017	2016-10-01	Added
FY2018	2017-10-01	No tabular change
FY2019	2018-10-01	Code-level rules changed
FY2020	2019-10-01	No tabular change
FY2020 · April	2020-04-01	No tabular change
FY2021	2020-10-01	No tabular change
FY2021 · 01-01	2021-01-01	No tabular change
FY2022	2021-10-01	Inherited rules changed
FY2022 · 04-01	2022-04-01	No tabular change
FY2023	2022-10-01	No tabular change
FY2023 · 04-01	2023-04-01	No tabular change
FY2024	2023-10-01	No tabular change
FY2024 · 04-01	2024-04-01	No tabular change
FY2025	2024-10-01	No tabular change
FY2025 · 04-01	2025-04-01	No tabular change
FY2026	2025-10-01	No tabular change
FY2026 · April	2026-04-01	No tabular change
FY2027	2026-10-01	No tabular change

Historical ICD-9 mappings · 2018

Historical mapping only; not an automatic code substitution.

558.3 · Approximate

CDC/NCHS · GEM 2018

Code-level instructions

Inclusion terms

FPIES

Use additional code

code for hypovolemic shock, if present (R57.1)

Inherited instructions

K52.2 · Allergic and dietetic gastroenteritis and colitis

Inclusion terms

Food hypersensitivity gastroenteritis or colitis

Excludes 2

allergic eosinophilic colitis (K52.82)
allergic eosinophilic esophagitis (K20.0)
allergic eosinophilic gastritis (K52.81)
allergic eosinophilic gastroenteritis (K52.81)

Use additional code

code to identify type of food allergy (Z91.01-, Z91.02-)

Chapters 11 · Diseases of the digestive system (K00-K95)

Excludes 2

certain conditions originating in the perinatal period (P04-P96)
certain infectious and parasitic diseases (A00-B99)
complications of pregnancy, childbirth and the puerperium (O00-O9A)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E88)
injury, poisoning and certain other consequences of external causes (S00-T88)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

K50-K52 · Noninfective enteritis and colitis (K50-K52)

Includes

noninfective inflammatory bowel disease

Excludes 1

irritable bowel syndrome (K58.-)
megacolon (K59.3-)

Official index references (7)

Allergy, allergic(reaction) (to) (1)

Allergy, allergic(reaction) (to) › milk protein › enterocolitis syndromeDisease index

Colitis(acute) (catarrhal) (chronic) (noninfective) (hemorrhagic) (1)

Colitis(acute) (catarrhal) (chronic) (noninfective) (hemorrhagic) › allergic › with › food protein-induced enterocolitis syndromeDisease index

Enteritis(acute) (diarrheal) (hemorrhagic) (noninfective) (2)

FPIES(food protein-induced enterocolitis syndrome) (1)

FPIES(food protein-induced enterocolitis syndrome)Disease index

Gastroenteritis(acute) (chronic) (noninfectious) (1)

Gastroenteritis(acute) (chronic) (noninfectious) › allergic › with › food protein-induced enterocolitis syndromeDisease index

Syndrome (1)

Syndrome › food protein-induced enterocolitis(FPIES)Disease index

Official conversion history

Historical assignments from the CDC conversion table support data retrieval. They do not authorize substituting a previous code for the current code.

Release dates 2016-10-01

Previous assignment: K52.2

Related codes

Other entries in the same category; these are not automatic substitutes.

Code	Description	Category · further specificity required
K52.22	Food protein-induced enteropathy	Billable / specific
K52.29	Other allergic and dietetic gastroenteritis and colitis	Billable / specific

Official titles and instructions are preserved in their source language. Official sources ↗

References from other codes (5)

K52.82 · Eosinophilic colitis

Excludes 2 · food protein-induced enterocolitis syndrome (FPIES) (K52.21)

T61 · Toxic effect of noxious substances eaten as seafood

Excludes 1 · food protein-induced enterocolitis syndrome (K52.21)

T62 · Toxic effect of other noxious substances eaten as food

Excludes 1 · food protein-induced enterocolitis syndrome (K52.21)

T78.1 · Other adverse food reactions, not elsewhere classified

Excludes 2 · food protein-induced enterocolitis syndrome (K52.21)

T78.4 · Other and unspecified allergy

Excludes 1 · food protein-induced enterocolitis syndrome (K52.21)

K52.21UpcomingBillable / specific

Food protein-induced enterocolitis syndrome

Code-level instructions

Use additional code

code for hypovolemic shock, if present (R57.1)

K52.2 · Inherited instructions

Use additional code

code to identify type of food allergy (Z91.01-, Z91.02-)

K50-K52 · Inherited instructions

Excludes 1

irritable bowel syndrome (K58.-)
megacolon (K59.3-)

Excludes 2 · 12

K52.2 · Allergic and dietetic gastroenteritis and colitis

Excludes 2

allergic eosinophilic colitis (K52.82)
allergic eosinophilic esophagitis (K20.0)
allergic eosinophilic gastritis (K52.81)
allergic eosinophilic gastroenteritis (K52.81)

Chapters 11 · Diseases of the digestive system (K00-K95)

Excludes 2

certain conditions originating in the perinatal period (P04-P96)
certain infectious and parasitic diseases (A00-B99)
complications of pregnancy, childbirth and the puerperium (O00-O9A)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E88)
injury, poisoning and certain other consequences of external causes (S00-T88)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Claims & coverage

Coverage depends on the payer, service and applicable policy. A billable code does not guarantee payment.

When ICD-10-CM is required

For US diagnosis claims covered by HIPAA, ICD-10-CM is required from October 1, 2015.

Official coding guidelines → · CMS ↗

Check Medicare coverage ↗

First observed · 2016-10-01

Code history

Latest recorded change · FY2022

ChangedUnchanged

FY2022

Effective from 2021-10-01

Inherited rules changed

Food protein-induced enterocolitis syndrome

Billable diagnosis code

CDC/NCHS · FY2022

All editions (18)

All editions	Effective from	Code history
FY2017	2016-10-01	Added
FY2018	2017-10-01	No tabular change
FY2019	2018-10-01	Code-level rules changed
FY2020	2019-10-01	No tabular change
FY2020 · April	2020-04-01	No tabular change
FY2021	2020-10-01	No tabular change
FY2021 · 01-01	2021-01-01	No tabular change
FY2022	2021-10-01	Inherited rules changed
FY2022 · 04-01	2022-04-01	No tabular change
FY2023	2022-10-01	No tabular change
FY2023 · 04-01	2023-04-01	No tabular change
FY2024	2023-10-01	No tabular change
FY2024 · 04-01	2024-04-01	No tabular change
FY2025	2024-10-01	No tabular change
FY2025 · 04-01	2025-04-01	No tabular change
FY2026	2025-10-01	No tabular change
FY2026 · April	2026-04-01	No tabular change
FY2027	2026-10-01	No tabular change

Historical ICD-9 mappings · 2018

Historical mapping only; not an automatic code substitution.

558.3 · Approximate

CDC/NCHS · GEM 2018

Code-level instructions

Inclusion terms

FPIES

Use additional code

code for hypovolemic shock, if present (R57.1)

Inherited instructions

K52.2 · Allergic and dietetic gastroenteritis and colitis

Inclusion terms

Food hypersensitivity gastroenteritis or colitis

Excludes 2

allergic eosinophilic colitis (K52.82)
allergic eosinophilic esophagitis (K20.0)
allergic eosinophilic gastritis (K52.81)
allergic eosinophilic gastroenteritis (K52.81)

Use additional code

code to identify type of food allergy (Z91.01-, Z91.02-)

Chapters 11 · Diseases of the digestive system (K00-K95)

Excludes 2

certain conditions originating in the perinatal period (P04-P96)
certain infectious and parasitic diseases (A00-B99)
complications of pregnancy, childbirth and the puerperium (O00-O9A)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E88)
injury, poisoning and certain other consequences of external causes (S00-T88)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

K50-K52 · Noninfective enteritis and colitis (K50-K52)

Includes

noninfective inflammatory bowel disease

Excludes 1

irritable bowel syndrome (K58.-)
megacolon (K59.3-)

Official index references (7)

Allergy, allergic(reaction) (to) (1)

Allergy, allergic(reaction) (to) › milk protein › enterocolitis syndromeDisease index

Colitis(acute) (catarrhal) (chronic) (noninfective) (hemorrhagic) (1)

Colitis(acute) (catarrhal) (chronic) (noninfective) (hemorrhagic) › allergic › with › food protein-induced enterocolitis syndromeDisease index

Enteritis(acute) (diarrheal) (hemorrhagic) (noninfective) (2)

FPIES(food protein-induced enterocolitis syndrome) (1)

FPIES(food protein-induced enterocolitis syndrome)Disease index

Gastroenteritis(acute) (chronic) (noninfectious) (1)

Gastroenteritis(acute) (chronic) (noninfectious) › allergic › with › food protein-induced enterocolitis syndromeDisease index

Syndrome (1)

Syndrome › food protein-induced enterocolitis(FPIES)Disease index

Official conversion history

Historical assignments from the CDC conversion table support data retrieval. They do not authorize substituting a previous code for the current code.

Release dates 2016-10-01

Previous assignment: K52.2

Related codes

Other entries in the same category; these are not automatic substitutes.

Code	Description	Category · further specificity required
K52.22	Food protein-induced enteropathy	Billable / specific
K52.29	Other allergic and dietetic gastroenteritis and colitis	Billable / specific

Official titles and instructions are preserved in their source language. Official sources ↗

References from other codes (5)

K52.82 · Eosinophilic colitis

Excludes 2 · food protein-induced enterocolitis syndrome (FPIES) (K52.21)

T61 · Toxic effect of noxious substances eaten as seafood

Excludes 1 · food protein-induced enterocolitis syndrome (K52.21)

T62 · Toxic effect of other noxious substances eaten as food

Excludes 1 · food protein-induced enterocolitis syndrome (K52.21)

T78.1 · Other adverse food reactions, not elsewhere classified

Excludes 2 · food protein-induced enterocolitis syndrome (K52.21)

T78.4 · Other and unspecified allergy

Excludes 1 · food protein-induced enterocolitis syndrome (K52.21)