A41UpcomingCategory · further specificity required

Other sepsis

Code-level instructions

Code first

, if applicable, postprocedural sepsis (T81.44-)
sepsis due to central venous catheter (T80.211-)
sepsis during labor (O75.3)
sepsis following abortion, ectopic or molar pregnancy (O03.37, O03.87, O04.87, O07.37, O08.82)
sepsis following immunization (T88.0-)
sepsis following infusion, transfusion or therapeutic injection (T80.22-, T80.29-)

Excludes 1

bacteremia NOS (R78.81)
neonatal (P36.-)
puerperal sepsis (O85)
streptococcal sepsis (A40.-)

Chapters 1 · Inherited instructions

Use additional code

code to identify resistance to antimicrobial drugs (Z16.-)

Excludes 2 · 18

A41

Excludes 2

sepsis (due to) (in) actinomycotic (A42.7)
sepsis (due to) (in) anthrax (A22.7)
sepsis (due to) (in) candidal (B37.7)
sepsis (due to) (in) Erysipelothrix (A26.7)
sepsis (due to) (in) extraintestinal yersiniosis (A28.2)
sepsis (due to) (in) gonococcal (A54.86)
sepsis (due to) (in) herpesviral (B00.7)
sepsis (due to) (in) listerial (A32.7)
sepsis (due to) (in) melioidosis (A24.1)
sepsis (due to) (in) meningococcal (A39.2-A39.4)
sepsis (due to) (in) plague (A20.7)
sepsis (due to) (in) tularemia (A21.7)
toxic shock syndrome (A48.3)

Chapters 1 · Certain infectious and parasitic diseases (A00-B99)

Excludes 2

carrier or suspected carrier of infectious disease (Z22.-)
certain localized infections - see body system-related chapters
infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)
infectious and parasitic diseases specific to the perinatal period (P35-P39)
influenza and other acute respiratory infections (J00-J22)

More specific codes

A41.0Sepsis due to Staphylococcus aureus A41.1Sepsis due to other specified staphylococcus A41.2Sepsis due to unspecified staphylococcus A41.3Sepsis due to Hemophilus influenzae A41.4Sepsis due to anaerobes A41.5Sepsis due to other Gram-negative organisms A41.8Other specified sepsis A41.9Sepsis, unspecified organism

Claims & coverage

When ICD-10-CM is required

For US diagnosis claims covered by HIPAA, ICD-10-CM is required from October 1, 2015.

Use the service date for outpatient/professional claims and the discharge date for hospital inpatient claims. Earlier encounters use ICD-9-CM; each individual code must also be valid for the applicable date.

Official coding guidelines → · CMS ↗

First observed · 2015-10-01

Code history

Latest recorded change · FY2027

ChangedUnchanged

FY2027UpcomingSelected edition

Effective from 2026-10-01

Inherited rules changed

Other sepsis

Category — select a more specific code

CDC/NCHS · FY2027

All editions (19)

All editions	Effective from	Code history
FY2016	2015-10-01	First observed
FY2017	2016-10-01	Code-level rules changed
FY2018	2017-10-01	No tabular change
FY2019	2018-10-01	No tabular change
FY2020	2019-10-01	No tabular change
FY2020 · April	2020-04-01	No tabular change
FY2021	2020-10-01	No tabular change
FY2021 · 01-01	2021-01-01	No tabular change
FY2022	2021-10-01	No tabular change
FY2022 · 04-01	2022-04-01	No tabular change
FY2023	2022-10-01	No tabular change
FY2023 · 04-01	2023-04-01	No tabular change
FY2024	2023-10-01	Code-level rules changed
FY2024 · 04-01	2024-04-01	No tabular change
FY2025	2024-10-01	No tabular change
FY2025 · 04-01	2025-04-01	No tabular change
FY2026	2025-10-01	No tabular change
FY2026 · April	2026-04-01	No tabular change
FY2027	2026-10-01	Inherited rules changed

Code-level instructions

Excludes 1

bacteremia NOS (R78.81)
neonatal (P36.-)
puerperal sepsis (O85)
streptococcal sepsis (A40.-)

Excludes 2

sepsis (due to) (in) actinomycotic (A42.7)
sepsis (due to) (in) anthrax (A22.7)
sepsis (due to) (in) candidal (B37.7)
sepsis (due to) (in) Erysipelothrix (A26.7)
sepsis (due to) (in) extraintestinal yersiniosis (A28.2)
sepsis (due to) (in) gonococcal (A54.86)
sepsis (due to) (in) herpesviral (B00.7)
sepsis (due to) (in) listerial (A32.7)
sepsis (due to) (in) melioidosis (A24.1)
sepsis (due to) (in) meningococcal (A39.2-A39.4)
sepsis (due to) (in) plague (A20.7)
sepsis (due to) (in) tularemia (A21.7)
toxic shock syndrome (A48.3)

Code first

, if applicable, postprocedural sepsis (T81.44-)
sepsis due to central venous catheter (T80.211-)
sepsis during labor (O75.3)
sepsis following abortion, ectopic or molar pregnancy (O03.37, O03.87, O04.87, O07.37, O08.82)
sepsis following immunization (T88.0-)
sepsis following infusion, transfusion or therapeutic injection (T80.22-, T80.29-)

Inherited instructions

Chapters 1 · Certain infectious and parasitic diseases (A00-B99)

Includes

diseases generally recognized as communicable or transmissible

Excludes 2

carrier or suspected carrier of infectious disease (Z22.-)
certain localized infections - see body system-related chapters
infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)
infectious and parasitic diseases specific to the perinatal period (P35-P39)
influenza and other acute respiratory infections (J00-J22)

Use additional code

code to identify resistance to antimicrobial drugs (Z16.-)

More specific codes

A41.0Sepsis due to Staphylococcus aureusCategory · further specificity required A41.1Sepsis due to other specified staphylococcusBillable / specific A41.2Sepsis due to unspecified staphylococcusBillable / specific A41.3Sepsis due to Hemophilus influenzaeBillable / specific A41.4Sepsis due to anaerobesBillable / specific A41.5Sepsis due to other Gram-negative organismsCategory · further specificity required A41.8Other specified sepsisCategory · further specificity required A41.9Sepsis, unspecified organismBillable / specific

Official index references (1)

Disorder(of) (1)

Disorder(of) › glomerular(in) › sepsis NECDisease index

Related codes

Official titles and instructions are preserved in their source language. Official sources ↗

References from other codes (7)

I5A · Non-ischemic myocardial injury (non-traumatic)

Code first · sepsis (A41.-)

J95.02 · Infection of tracheostomy stoma

Use additional code · sepsis (A40, A41.-)

K94.02 · Colostomy infection

Use additional code · sepsis (A40.-, A41.-)

K94.12 · Enterostomy infection

Use additional code · sepsis (A40.-, A41.-)

K94.22 · Gastrostomy infection

Use additional code · sepsis (A40.-, A41.-)

K95.01 · Infection due to gastric band procedure

Use additional code · sepsis (A40.-, A41.-)

K95.81 · Infection due to other bariatric procedure

Use additional code · sepsis (A40.-, A41.-)

A41UpcomingCategory · further specificity required

Other sepsis

Code-level instructions

Code first

, if applicable, postprocedural sepsis (T81.44-)
sepsis due to central venous catheter (T80.211-)
sepsis during labor (O75.3)
sepsis following abortion, ectopic or molar pregnancy (O03.37, O03.87, O04.87, O07.37, O08.82)
sepsis following immunization (T88.0-)
sepsis following infusion, transfusion or therapeutic injection (T80.22-, T80.29-)

Excludes 1

bacteremia NOS (R78.81)
neonatal (P36.-)
puerperal sepsis (O85)
streptococcal sepsis (A40.-)

Chapters 1 · Inherited instructions

Use additional code

code to identify resistance to antimicrobial drugs (Z16.-)

Excludes 2 · 18

A41

Excludes 2

sepsis (due to) (in) actinomycotic (A42.7)
sepsis (due to) (in) anthrax (A22.7)
sepsis (due to) (in) candidal (B37.7)
sepsis (due to) (in) Erysipelothrix (A26.7)
sepsis (due to) (in) extraintestinal yersiniosis (A28.2)
sepsis (due to) (in) gonococcal (A54.86)
sepsis (due to) (in) herpesviral (B00.7)
sepsis (due to) (in) listerial (A32.7)
sepsis (due to) (in) melioidosis (A24.1)
sepsis (due to) (in) meningococcal (A39.2-A39.4)
sepsis (due to) (in) plague (A20.7)
sepsis (due to) (in) tularemia (A21.7)
toxic shock syndrome (A48.3)

Chapters 1 · Certain infectious and parasitic diseases (A00-B99)

Excludes 2

carrier or suspected carrier of infectious disease (Z22.-)
certain localized infections - see body system-related chapters
infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)
infectious and parasitic diseases specific to the perinatal period (P35-P39)
influenza and other acute respiratory infections (J00-J22)

More specific codes

Claims & coverage

When ICD-10-CM is required

For US diagnosis claims covered by HIPAA, ICD-10-CM is required from October 1, 2015.

Official coding guidelines → · CMS ↗

First observed · 2015-10-01

Code history

Latest recorded change · FY2027

ChangedUnchanged

FY2027UpcomingSelected edition

Effective from 2026-10-01

Inherited rules changed

Other sepsis

Category — select a more specific code

CDC/NCHS · FY2027

All editions (19)

All editions	Effective from	Code history
FY2016	2015-10-01	First observed
FY2017	2016-10-01	Code-level rules changed
FY2018	2017-10-01	No tabular change
FY2019	2018-10-01	No tabular change
FY2020	2019-10-01	No tabular change
FY2020 · April	2020-04-01	No tabular change
FY2021	2020-10-01	No tabular change
FY2021 · 01-01	2021-01-01	No tabular change
FY2022	2021-10-01	No tabular change
FY2022 · 04-01	2022-04-01	No tabular change
FY2023	2022-10-01	No tabular change
FY2023 · 04-01	2023-04-01	No tabular change
FY2024	2023-10-01	Code-level rules changed
FY2024 · 04-01	2024-04-01	No tabular change
FY2025	2024-10-01	No tabular change
FY2025 · 04-01	2025-04-01	No tabular change
FY2026	2025-10-01	No tabular change
FY2026 · April	2026-04-01	No tabular change
FY2027	2026-10-01	Inherited rules changed

Code-level instructions

Excludes 1

bacteremia NOS (R78.81)
neonatal (P36.-)
puerperal sepsis (O85)
streptococcal sepsis (A40.-)

Excludes 2

sepsis (due to) (in) actinomycotic (A42.7)
sepsis (due to) (in) anthrax (A22.7)
sepsis (due to) (in) candidal (B37.7)
sepsis (due to) (in) Erysipelothrix (A26.7)
sepsis (due to) (in) extraintestinal yersiniosis (A28.2)
sepsis (due to) (in) gonococcal (A54.86)
sepsis (due to) (in) herpesviral (B00.7)
sepsis (due to) (in) listerial (A32.7)
sepsis (due to) (in) melioidosis (A24.1)
sepsis (due to) (in) meningococcal (A39.2-A39.4)
sepsis (due to) (in) plague (A20.7)
sepsis (due to) (in) tularemia (A21.7)
toxic shock syndrome (A48.3)

Code first

, if applicable, postprocedural sepsis (T81.44-)
sepsis due to central venous catheter (T80.211-)
sepsis during labor (O75.3)
sepsis following abortion, ectopic or molar pregnancy (O03.37, O03.87, O04.87, O07.37, O08.82)
sepsis following immunization (T88.0-)
sepsis following infusion, transfusion or therapeutic injection (T80.22-, T80.29-)

Inherited instructions

Chapters 1 · Certain infectious and parasitic diseases (A00-B99)

Includes

diseases generally recognized as communicable or transmissible

Excludes 2

carrier or suspected carrier of infectious disease (Z22.-)
certain localized infections - see body system-related chapters
infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)
infectious and parasitic diseases specific to the perinatal period (P35-P39)
influenza and other acute respiratory infections (J00-J22)

Use additional code

code to identify resistance to antimicrobial drugs (Z16.-)

More specific codes

Official index references (1)

Disorder(of) (1)

Disorder(of) › glomerular(in) › sepsis NECDisease index

Related codes

Official titles and instructions are preserved in their source language. Official sources ↗

References from other codes (7)

I5A · Non-ischemic myocardial injury (non-traumatic)

Code first · sepsis (A41.-)

J95.02 · Infection of tracheostomy stoma

Use additional code · sepsis (A40, A41.-)

K94.02 · Colostomy infection

Use additional code · sepsis (A40.-, A41.-)

K94.12 · Enterostomy infection

Use additional code · sepsis (A40.-, A41.-)

K94.22 · Gastrostomy infection

Use additional code · sepsis (A40.-, A41.-)

K95.01 · Infection due to gastric band procedure

Use additional code · sepsis (A40.-, A41.-)

K95.81 · Infection due to other bariatric procedure

Use additional code · sepsis (A40.-, A41.-)