Effective from
- Inherited rules changed
Poisoning by, adverse effect of and underdosing of immune checkpoint inhibitors and immunostimulant drugs
Category — select a more specific code
CDC/NCHS · FY2025 · 04-01poisoning by, adverse effect of and underdosing of antineoplastic and immunosuppressive drug (T45.1)
code to identify any retained foreign body, if applicable (Z18.-)
toxic reaction to local anesthesia in pregnancy (O29.3-)
A — initial encounter
D — subsequent encounter
S — sequela
For US diagnosis claims covered by HIPAA, ICD-10-CM is required from October 1, 2015.
Use the service date for outpatient/professional claims and the discharge date for hospital inpatient claims. Earlier encounters use ICD-9-CM; each individual code must also be valid for the applicable date.
Official coding guidelines → · CMS ↗First observed · 2024-10-01
Latest recorded change · FY2025 · 04-01
Effective from
Poisoning by, adverse effect of and underdosing of immune checkpoint inhibitors and immunostimulant drugs
Category — select a more specific code
CDC/NCHS · FY2025 · 04-01| All editions | Effective from | Code history |
|---|---|---|
| FY2025 | 2024-10-01 | Added |
| FY2025 · 04-01 | 2025-04-01 | Inherited rules changed |
| FY2026 | 2025-10-01 | No tabular change |
| FY2026 · April | 2026-04-01 | No tabular change |
| FY2027 | 2026-10-01 | No tabular change |
poisoning by, adverse effect of and underdosing of antineoplastic and immunosuppressive drug (T45.1)
code to identify any retained foreign body, if applicable (Z18.-)
toxic reaction to local anesthesia in pregnancy (O29.3-)
The appropriate 7th character is to be added to each code from category T45
A — initial encounter
D — subsequent encounter
S — sequela
Other entries in the same category; these are not automatic substitutes.
| Code | Description | Category · further specificity required |
|---|---|---|
| T45.0 | Poisoning by, adverse effect of and underdosing of antiallergic and antiemetic drugs | Category · further specificity required |
| T45.1 | Poisoning by, adverse effect of and underdosing of antineoplastic and immunosuppressive drugs | Category · further specificity required |
| T45.2 | Poisoning by, adverse effect of and underdosing of vitamins | Category · further specificity required |
| T45.3 | Poisoning by, adverse effect of and underdosing of enzymes | Category · further specificity required |
| T45.4 | Poisoning by, adverse effect of and underdosing of iron and its compounds | Category · further specificity required |
| T45.5 | Poisoning by, adverse effect of and underdosing of anticoagulants and antithrombotic drugs | Category · further specificity required |
| T45.6 | Poisoning by, adverse effect of and underdosing of fibrinolysis-affecting drugs | Category · further specificity required |
| T45.7 | Poisoning by, adverse effect of and underdosing of anticoagulant antagonists, vitamin K and other coagulants | Category · further specificity required |
| T45.8 | Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents | Category · further specificity required |
| T45.9 | Poisoning by, adverse effect of and underdosing of unspecified primarily systemic and hematological agent | Category · further specificity required |
Official titles and instructions are preserved in their source language. Official sources ↗