D89.83CurrentCategory · further specificity required

Cytokine release syndrome

Code-level instructions

Code first

underlying cause, such as:
complications following infusion, transfusion and therapeutic injection (T80.89-)
complications of transplanted organs and tissue (T86.-)

Use additional code

code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5)
code to identify associated manifestations

D80-D89 · Inherited instructions

Excludes 1

autoimmune disease (systemic) NOS (M35.9)
functional disorders of polymorphonuclear neutrophils (D71-)
human immunodeficiency virus [HIV] disease (B20)

D89 · Inherited instructions

Excludes 1

hyperglobulinemia NOS (R77.1)
monoclonal gammopathy (of undetermined significance) (D47.2)

Excludes 2 · 10

Chapters 3 · Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

Excludes 2

autoimmune disease (systemic) NOS (M35.9)
certain conditions originating in the perinatal period (P00-P96)
complications of pregnancy, childbirth and the puerperium (O00-O9A)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E88)
human immunodeficiency virus [HIV] disease (B20)
injury, poisoning and certain other consequences of external causes (S00-T88)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

D89 · Other disorders involving the immune mechanism, not elsewhere classified

Excludes 2

transplant failure and rejection (T86.-)

More specific codes

D89.831Cytokine release syndrome, grade 1 D89.832Cytokine release syndrome, grade 2 D89.833Cytokine release syndrome, grade 3 D89.834Cytokine release syndrome, grade 4 D89.835Cytokine release syndrome, grade 5 D89.839Cytokine release syndrome, grade unspecified

Claims & coverage

When ICD-10-CM is required

For US diagnosis claims covered by HIPAA, ICD-10-CM is required from October 1, 2015.

Use the service date for outpatient/professional claims and the discharge date for hospital inpatient claims. Earlier encounters use ICD-9-CM; each individual code must also be valid for the applicable date.

Official coding guidelines → · CMS ↗

First observed · 2020-10-01

Code history

Latest recorded change · FY2027

ChangedUnchanged

FY2027Upcoming

Effective from 2026-10-01

Inherited rules changed

Cytokine release syndrome

Category — select a more specific code

CDC/NCHS · FY2027

All editions (13)

All editions	Effective from	Code history
FY2021	2020-10-01	Added
FY2021 · 01-01	2021-01-01	No tabular change
FY2022	2021-10-01	No tabular change
FY2022 · 04-01	2022-04-01	No tabular change
FY2023	2022-10-01	No tabular change
FY2023 · 04-01	2023-04-01	No tabular change
FY2024	2023-10-01	No tabular change
FY2024 · 04-01	2024-04-01	No tabular change
FY2025	2024-10-01	Code-level rules changed
FY2025 · 04-01	2025-04-01	No tabular change
FY2026	2025-10-01	Inherited rules changed
FY2026 · April	2026-04-01	No tabular change
FY2027	2026-10-01	Inherited rules changed

Code-level instructions

Code first

underlying cause, such as:
complications following infusion, transfusion and therapeutic injection (T80.89-)
complications of transplanted organs and tissue (T86.-)

Use additional code

code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5)
code to identify associated manifestations

Inherited instructions

Chapters 3 · Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

Excludes 2

autoimmune disease (systemic) NOS (M35.9)
certain conditions originating in the perinatal period (P00-P96)
complications of pregnancy, childbirth and the puerperium (O00-O9A)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E88)
human immunodeficiency virus [HIV] disease (B20)
injury, poisoning and certain other consequences of external causes (S00-T88)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

D80-D89 · Certain disorders involving the immune mechanism (D80-D89)

Includes

defects in the complement system
immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
sarcoidosis

Excludes 1

autoimmune disease (systemic) NOS (M35.9)
functional disorders of polymorphonuclear neutrophils (D71-)
human immunodeficiency virus [HIV] disease (B20)

D89 · Other disorders involving the immune mechanism, not elsewhere classified

Excludes 1

hyperglobulinemia NOS (R77.1)
monoclonal gammopathy (of undetermined significance) (D47.2)

Excludes 2

transplant failure and rejection (T86.-)

More specific codes

D89.831Cytokine release syndrome, grade 1Billable / specific D89.832Cytokine release syndrome, grade 2Billable / specific D89.833Cytokine release syndrome, grade 3Billable / specific D89.834Cytokine release syndrome, grade 4Billable / specific D89.835Cytokine release syndrome, grade 5Billable / specific D89.839Cytokine release syndrome, grade unspecifiedBillable / specific

Related codes

Other entries in the same category; these are not automatic substitutes.

Code	Description	Category · further specificity required
D89.81	Graft-versus-host disease	Category · further specificity required
D89.82	Autoimmune lymphoproliferative syndrome [ALPS]	Billable / specific
D89.84	IgG4-related disease	Billable / specific
D89.89	Other specified disorders involving the immune mechanism, not elsewhere classified	Billable / specific

Official titles and instructions are preserved in their source language. Official sources ↗

D89.83CurrentCategory · further specificity required

Cytokine release syndrome

Code-level instructions

Code first

underlying cause, such as:
complications following infusion, transfusion and therapeutic injection (T80.89-)
complications of transplanted organs and tissue (T86.-)

Use additional code

code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5)
code to identify associated manifestations

D80-D89 · Inherited instructions

Excludes 1

autoimmune disease (systemic) NOS (M35.9)
functional disorders of polymorphonuclear neutrophils (D71-)
human immunodeficiency virus [HIV] disease (B20)

D89 · Inherited instructions

Excludes 1

hyperglobulinemia NOS (R77.1)
monoclonal gammopathy (of undetermined significance) (D47.2)

Excludes 2 · 10

Chapters 3 · Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

Excludes 2

autoimmune disease (systemic) NOS (M35.9)
certain conditions originating in the perinatal period (P00-P96)
complications of pregnancy, childbirth and the puerperium (O00-O9A)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E88)
human immunodeficiency virus [HIV] disease (B20)
injury, poisoning and certain other consequences of external causes (S00-T88)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

D89 · Other disorders involving the immune mechanism, not elsewhere classified

Excludes 2

transplant failure and rejection (T86.-)

More specific codes

Claims & coverage

When ICD-10-CM is required

For US diagnosis claims covered by HIPAA, ICD-10-CM is required from October 1, 2015.

Official coding guidelines → · CMS ↗

First observed · 2020-10-01

Code history

Latest recorded change · FY2027

ChangedUnchanged

FY2027Upcoming

Effective from 2026-10-01

Inherited rules changed

Cytokine release syndrome

Category — select a more specific code

CDC/NCHS · FY2027

All editions (13)

All editions	Effective from	Code history
FY2021	2020-10-01	Added
FY2021 · 01-01	2021-01-01	No tabular change
FY2022	2021-10-01	No tabular change
FY2022 · 04-01	2022-04-01	No tabular change
FY2023	2022-10-01	No tabular change
FY2023 · 04-01	2023-04-01	No tabular change
FY2024	2023-10-01	No tabular change
FY2024 · 04-01	2024-04-01	No tabular change
FY2025	2024-10-01	Code-level rules changed
FY2025 · 04-01	2025-04-01	No tabular change
FY2026	2025-10-01	Inherited rules changed
FY2026 · April	2026-04-01	No tabular change
FY2027	2026-10-01	Inherited rules changed

Code-level instructions

Code first

underlying cause, such as:
complications following infusion, transfusion and therapeutic injection (T80.89-)
complications of transplanted organs and tissue (T86.-)

Use additional code

code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5)
code to identify associated manifestations

Inherited instructions

Chapters 3 · Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

Excludes 2

autoimmune disease (systemic) NOS (M35.9)
certain conditions originating in the perinatal period (P00-P96)
complications of pregnancy, childbirth and the puerperium (O00-O9A)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E88)
human immunodeficiency virus [HIV] disease (B20)
injury, poisoning and certain other consequences of external causes (S00-T88)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

D80-D89 · Certain disorders involving the immune mechanism (D80-D89)

Includes

defects in the complement system
immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
sarcoidosis

Excludes 1

autoimmune disease (systemic) NOS (M35.9)
functional disorders of polymorphonuclear neutrophils (D71-)
human immunodeficiency virus [HIV] disease (B20)

D89 · Other disorders involving the immune mechanism, not elsewhere classified

Excludes 1

hyperglobulinemia NOS (R77.1)
monoclonal gammopathy (of undetermined significance) (D47.2)

Excludes 2

transplant failure and rejection (T86.-)

More specific codes

Related codes

Other entries in the same category; these are not automatic substitutes.

Code	Description	Category · further specificity required
D89.81	Graft-versus-host disease	Category · further specificity required
D89.82	Autoimmune lymphoproliferative syndrome [ALPS]	Billable / specific
D89.84	IgG4-related disease	Billable / specific
D89.89	Other specified disorders involving the immune mechanism, not elsewhere classified	Billable / specific

Official titles and instructions are preserved in their source language. Official sources ↗